Glycols & Polyols Available to Source

Tromethamine USP NF

CAS 77-86-1 · MF C4H11NO3 · MW 121.14 g/mol

A pH-adjusting agent used in cosmetics and pharmaceutical formulations; also acts as a buffering agent.

SDS / TDS Download
CAS Number
77-86-1
Molecular Formula
C4H11NO3
Molecular Weight
121.14 g/mol
Material Family
Glycols & Polyols
Functional Roles
Physical Properties
melting_point
171-172 u00b0C
boiling_point
219-220 u00b0C at 10 mm Hg
solubility
79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride
vapor_pressure
0.000022 [mmHg]
ph
pH of 0.1 molar aq soln = 10.4
GHS / SDS Safety Warning
Irritant
  • H315 (80.2%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H335 (70.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
  • H319 (80.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Chemical Identity
CAS Number77-86-1
IUPAC Name2-amino-2-(hydroxymethyl)propane-1,3-diol
InChI KeyLENZDBCJOHFCAS-UHFFFAOYSA-N
PubChem CID 6503
INCI NameTROMETHAMINE
Synonyms & Trade Names
Trometamol TROMETHAMINE Tris(Hydroxymethyl)aminomethane Tham Trisamine 2-Amino-2-(hydroxymethyl)-1,3-propanediol Tris buffer Tromethane Tris-base Trisaminol Pehanorm Talatrol Tutofusin tris Tris-steril Addex-tham
Full Description

A pH-adjusting agent used in cosmetics and pharmaceutical formulations; also acts as a buffering agent.