Functional Roles
Industries Served
Physical Properties
physical_description
Hexamethylene diisocyanate appears as a colorless crystalline solid. Toxic by ingestion and is strongly irritating to skin and eyes. It is used to make nylon.
color/form
Clear, colorless to slightly yellow liquid
odor
Sharp, pungent odor
boiling_point
491 u00b0F at 760 mmHg (NTP, 1992)
melting_point
-67 u00b0F (NTP, 1992)
flash_point
284 u00b0F (NTP, 1992)
solubility
Reacts with water (NTP, 1992)
density
1.0528 at 68 u00b0F (NTP, 1992) - Denser than water; will sink
vapor_density
Relative vapor density (air = 1): 5.8
vapor_pressure
0.05 mmHg at 75 u00b0F (NTP, 1992)
logp
1.08
autoignition_temperature
454 u00b0C
decomposition
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
odor_threshold
The absolute perception limit is 0.001 ppm and 100% recognition at 0.02 ppm.
refractive_index
Index of refraction: 1.4585 at 20 u00b0C/D
other_experimental_properties
Hexamethylene diisocyanate reacts with compounds that contain active hydrogens, such as water, ammonia, amines and alcohols; strong bases (such as tertiary amines, caustic soda and potash) can catalyze these reactions and result in uncontrolled polymerization
GHS / SDS Safety
Danger
Irritant
Acute Toxic
Health Hazard
Corrosive
- H319 (97.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]
- H330 (77%): Fatal if inhaled [Danger Acute toxicity, inhalation]
- H302: Harmful if swallowed [Warning Acute toxicity, oral]
- H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H315: Causes skin irritation [Warning Skin corrosion/irritation]
- H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
- H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
- H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
- H330: Fatal if inhaled [Danger Acute toxicity, inhalation]
- H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
- H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
- H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
- H334 (> 99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
- H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
- H302 (78.6%): Harmful if swallowed [Warning Acute toxicity, oral]
- H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
- H331 (23.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]
- H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
- H315 (97.2%): Causes skin irritation [Warning Skin corrosion/irritation]
- H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
Chemical Identity
| CAS Number | 822-06-0 |
| IUPAC Name | 1,6-diisocyanatohexane |
| InChI Key | RRAMGCGOFNQTLD-UHFFFAOYSA-N |
| PubChem CID | 13192 |
| INCI Name | 1,6-HEXAMETHYLENE DIISOCYANATE |
Synonyms & Trade Names
Full Description
Hexamethylene diisocyanate (HDI) is an aliphatic diisocyanate compound with the molecular formula C8H12N2O2 that functions as a crosslinking and curing agent in polymer systems. This chemical is utilized across coatings & construction, industrial manufacturing, and plastics & polymers industries for applications requiring durable chemical bonds and enhanced material properties. HDI reacts with water and exhibits a density of 1.0528 at 68°F with a flash point of 284°F.